{ "_id": "6a1f368eb401979e7342896a", "Package": "dosresmeta", "Type": "Package", "Title": "Multivariate Dose-Response Meta-Analysis", "Version": "2.2.0", "Date": "2025-04-18", "Authors@R": "person(\"Alessio\", \"Crippa\", email = \"alessio.crippa@ki.se\",\nrole = c(\"aut\", \"cre\"))", "Maintainer": "Alessio Crippa ", "Description": "Estimates dose-response relations from summarized\ndose-response data and to combines them according to principles\nof (multivariate) random-effects models.", "URL": "https://alecri.github.io/software/dosresmeta.html", "BugReports": "https://github.com/alecri/dosresmeta/issues", "License": "GPL-2", "RoxygenNote": "7.3.2", "Encoding": "UTF-8", "VignetteBuilder": "knitr", "Repository": "https://alecri.r-universe.dev", "Date/Publication": "2025-04-19 18:07:31 UTC", "RemoteUrl": "https://github.com/alecri/dosresmeta", "RemoteRef": "HEAD", "RemoteSha": "85cfe30a155add28a5a12cba9adf5deb60a457af", "NeedsCompilation": "no", "Packaged": { "Date": "2026-05-15 06:15:39 UTC", "User": "root" }, "Author": "Alessio Crippa [aut, cre]", "MD5sum": "15f0208220836b35d7951b4d0e69a088", "_user": "alecri", "_type": "src", "_file": "dosresmeta_2.2.0.tar.gz", "_fileid": "e29bca216e1f3679991cd565b2fb3d558dd77b627552261738eff8bd4b3b73d6", "_filesize": 805014, "_sha256": "e29bca216e1f3679991cd565b2fb3d558dd77b627552261738eff8bd4b3b73d6", "_created": "2026-05-15T06:15:39.000Z", "_published": "2026-06-02T20:01:18.225Z", "_distro": "noble", "_jobs": [ { "job": 79160523179, "time": 157, "config": "linux-devel-x86_64", "r": "4.7.0", "check": "OK", "artifact": "7011280600" }, { "job": 79160523026, "time": 135, "config": "linux-release-x86_64", "r": "4.6.0", "check": "OK", "artifact": "7011275632" }, { "job": 79160523216, "time": 184, "config": "macos-oldrel-arm64", "r": "4.5.3", "check": "OK", "artifact": "7011280951" }, { "job": 79160523307, "time": 143, "config": "macos-release-arm64", "r": "4.6.0", "check": "OK", "artifact": "7011270702" }, { "job": 79160522556, "time": 229, "config": "source", "r": "4.6.0", "check": "OK", "artifact": "7011246021" }, { "job": 79160522388, "time": 109, "config": "wasm-release", "r": "4.6.0", "check": "OK", "artifact": "7368438729" }, { "job": 79160523018, "time": 88, "config": "windows-devel", "r": "4.7.0", "check": "OK", "artifact": "7011265339" }, { "job": 79160523049, "time": 73, "config": "windows-oldrel", "r": "4.5.3", "check": "OK", "artifact": "7011262041" }, { "job": 79160523285, "time": 81, "config": "windows-release", "r": "4.6.0", "check": "OK", "artifact": "7011263564" } ], "_buildurl": "https://github.com/r-universe/alecri/actions/runs/25903363092", "_status": "success", "_host": "GitHub-Actions", "_upstream": "https://github.com/alecri/dosresmeta", "_commit": { "id": "85cfe30a155add28a5a12cba9adf5deb60a457af", "author": "Alessio Crippa ", "committer": "Alessio Crippa ", "message": "one more warning fixed\n", "time": 1745086051 }, "_maintainer": { "name": "Alessio Crippa", "email": "alessio.crippa@ki.se" }, "_registered": true, "_dependencies": [ { "package": "mixmeta", "role": "Depends" }, { "package": "knitr", "role": "Suggests" }, { "package": "rmarkdown", "role": "Suggests" }, { "package": "rms", "role": "Suggests" } ], "_owner": "alecri", "_selfowned": true, "_usedby": 0, "_updates": [], "_tags": [], "_stars": 13, "_contributors": [ { "user": "alecri", "count": 38, "uuid": 5814311 } ], "_userbio": { "uuid": 5814311, "type": "user", "name": "Alessio Crippa" }, "_downloads": { "count": 2041, "source": "https://cranlogs.r-pkg.org/downloads/total/last-month/dosresmeta" }, "_mentions": 27, "_devurl": "https://github.com/alecri/dosresmeta", "_searchresults": 86, "_rbuild": "4.6.0", "_assets": [ "extra/citation.cff", "extra/citation.html", "extra/citation.json", "extra/citation.txt", "extra/contents.json", "extra/dosresmeta.html", "extra/readme.html", "extra/readme.md", "manual.pdf" ], "_homeurl": "https://github.com/alecri/dosresmeta", "_realowner": "alecri", "_cranurl": true, "_releases": [ { "version": "1.0", "date": "2013-09-09" }, { "version": "1.1", "date": "2013-09-15" }, { "version": "1.2", "date": "2013-10-02" }, { "version": "1.2.1", "date": "2013-10-17" }, { "version": "1.2.2", "date": "2013-12-02" }, { "version": "1.3.0", "date": "2014-01-17" }, { "version": "1.3.2", "date": "2015-08-11" }, { "version": "1.3.3", "date": "2016-08-08" }, { "version": "2.0.0", "date": "2017-08-17" }, { "version": "2.0.1", "date": "2017-09-12" }, { "version": "2.2.0", "date": "2025-04-19" } ], "_exports": [ "covar.logrr", "covar.smd", "dosresmeta", "dosresmeta.control", "dosresmeta.fit", "fpgrid", "fracpol", "gof", "grl", "hamling", "vpc", "waldtest" ], "_datasets": [ { "name": "alcohol_crc", "title": "Eight published studies on the relation between alcohol intake and colorectal cancer", "object": "alcohol_crc", "file": "alcohol_crc.rda", "class": [ "data.frame" ], "fields": [ "id", "type", "dose", "cases", "peryears", "logrr", "se" ], "rows": 48, "table": true, "tojson": true }, { "name": "alcohol_cvd", "title": "Six published studies on the relation between alcohol intake and cardiovascular disease risk", "object": "alcohol_cvd", "file": "alcohol_cvd.rda", "class": [ "data.frame" ], "fields": [ "id", "author", "type", "dose", "cases", "n", "logrr", "se" ], "rows": 25, "table": true, "tojson": true }, { "name": "alcohol_esoph", "title": "Fourteen case-control studies on the relation between alcohol consumption and esophageal cancer", "object": "alcohol_esoph", "file": "alcohol_esoph.rda", "class": [ "data.frame" ], "fields": [ "id", "author", "type", "cases", "n", "logrr", "dose", "se", "dosep1", "dosep2" ], "rows": 63, "table": true, "tojson": true }, { "name": "alcohol_lc", "title": "Four published studies on the relation between alcohol intake and lung cancer", "object": "alcohol_lc", "file": "alcohol_lc.rda", "class": [ "data.frame" ], "fields": [ "id", "type", "dose", "cases", "peryears", "logrr", "se" ], "rows": 20, "table": true, "tojson": true }, { "name": "ari", "title": "Five clinical trials on the relation between aripiprazole and schizophrenia", "object": "ari", "file": "ari.rda", "class": [ "data.frame" ], "fields": [ "id", "author", "dose", "y", "sd", "n" ], "rows": 18, "table": true, "tojson": true }, { "name": "bmi_rc", "title": "Four case-control studies on the relation between Body Mass Index and renal cell cancer", "object": "bmi_rc", "file": "bmi_rc.rda", "class": [ "data.frame" ], "fields": [ "id", "author", "type", "interval", "bmi", "case", "control", "n", "or", "lb_or", "ub_or", "logor", "se_logor" ], "rows": 33, "table": true, "tojson": true }, { "name": "cc_ex", "title": "Case-control data on alcohol and breast cancer risk", "object": "cc_ex", "file": "cc_ex.rda", "class": [ "data.frame" ], "fields": [ "gday", "dose", "case", "control", "n", "crudeor", "adjrr", "lb", "ub", "logrr" ], "rows": 4, "table": true, "tojson": true }, { "name": "ci_ex", "title": "Cumulative incidence data on high-fat dairy food and colorectal cancer risk", "object": "ci_ex", "file": "ci_ex.rda", "class": [ "data.frame" ], "fields": [ "dose", "cases", "n", "adjrr", "lb", "ub", "logrr", "se" ], "rows": 5, "table": true, "tojson": true }, { "name": "coffee_cancer", "title": "Eight prospective studies on the relation between coffee consumption and cancer mortality", "object": "coffee_cancer", "file": "coffee_cancer.rda", "class": [ "data.frame" ], "fields": [ "id", "author", "year", "type", "dose", "cases", "n", "logrr", "se" ], "rows": 59, "table": true, "tojson": true }, { "name": "coffee_cvd", "title": "Thirteen prospective studies on the relation between coffee consumption and cardiovascular mortality", "object": "coffee_cvd", "file": "coffee_cvd.rda", "class": [ "data.frame" ], "fields": [ "id", "author", "year", "type", "dose", "cases", "n", "logrr", "se", "gender", "area", "smoking" ], "rows": 92, "table": true, "tojson": true }, { "name": "coffee_mort", "title": "Twenty-one prospective studies on the relation between coffee consumption and all-cause mortality", "object": "coffee_mort", "file": "coffee_mort.rda", "class": [ "data.frame" ], "fields": [ "id", "author", "year", "type", "dose", "cases", "n", "logrr", "se", "gender", "area" ], "rows": 101, "table": true, "tojson": true }, { "name": "coffee_mort_add", "title": "Additional two prospective studies on the relation between coffee consumption and all-cause mortality", "object": "coffee_mort_add", "file": "coffee_mort_add.rda", "class": [ "data.frame" ], "fields": [ "id", "author", "year", "type", "dose", "cases", "n", "logrr", "se", "gender", "area" ], "rows": 29, "table": true, "tojson": true }, { "name": "coffee_stroke", "title": "Eleven prospective studies on the relation between coffee consumption and stroke risk", "object": "coffee_stroke", "file": "coffee_stroke.rda", "class": [ "data.frame" ], "fields": [ "id", "author", "type", "dose", "cases", "n", "rr", "lb", "ub", "logrr", "se", "nordic" ], "rows": 68, "table": true, "tojson": true }, { "name": "fish_ra", "title": "Six studies on the relation between fish consumption and rheumatoid arthritis risk", "object": "fish_ra", "file": "fish_ra.rda", "class": [ "data.frame" ], "fields": [ "id", "author", "year", "type", "dose", "cases", "n", "rr", "lrr", "urr", "logrr", "se" ], "rows": 22, "table": true, "tojson": true }, { "name": "ir_ex", "title": "Incidence-rate data on fiber intake and coronary heart disease risk", "object": "ir_ex", "file": "ir_ex.rda", "class": [ "data.frame" ], "fields": [ "dose", "cases", "n", "adjrr", "lb", "ub", "logrr", "se" ], "rows": 5, "table": true, "tojson": true }, { "name": "milk_mort", "title": "Eleven prospective studies on the relation between milk consumption and all-cause mortality", "object": "milk_mort", "file": "milk_mort.rda", "class": [ "data.frame" ], "fields": [ "id", "author", "year", "type", "dose", "cases", "n", "rr", "lb", "ub", "logrr", "se" ], "rows": 56, "table": true, "tojson": true }, { "name": "milk_ov", "title": "Nine studies on the relation between milk consumption and ovarian cancer", "object": "milk_ov", "file": "milk_ov.rda", "class": [ "data.frame" ], "fields": [ "id", "author", "year", "type", "dose", "case", "n", "adjrr", "lb", "ub", "logrr", "se" ], "rows": 37, "table": true, "tojson": true }, { "name": "oc_breast", "title": "Twenty-two case-control studies on the relation between oral contraceptives use and breast cancer", "object": "oc_breast", "file": "oc_breast.rda", "class": [ "data.frame" ], "fields": [ "id", "author", "year", "type", "duration", "cases", "n", "or", "lb", "ub", "logor", "se", "menopause", "period" ], "rows": 113, "table": true, "tojson": true }, { "name": "process_bc", "title": "Ten studies on the relation between processed meat and bladder cancer", "object": "process_bc", "file": "process_bc.rda", "class": [ "data.frame" ], "fields": [ "id", "author", "year", "type", "dose0", "dose", "cases", "n", "rr", "lrr", "urr", "logrr", "se", "area", "unit" ], "rows": 46, "table": true, "tojson": true }, { "name": "red_bc", "title": "Twelve studies on the relation between red meat and bladder cancer", "object": "red_bc", "file": "red_bc.rda", "class": [ "data.frame" ], "fields": [ "id", "author", "year", "type", "dose0", "dose", "cases", "n", "rr", "lrr", "urr", "logrr", "se", "area", "unit" ], "rows": 51, "table": true, "tojson": true }, { "name": "sim_os", "title": "Simulated data for one-stage dose-response meta-analysis", "object": "sim_os", "file": "sim_os.rda", "class": [ "data.frame" ], "fields": [ "xcati", "id", "type", "dose", "cases", "n", "rr", "lrr", "urr", "logrr", "se" ], "rows": 27, "table": true, "tojson": true } ], "_help": [ { "page": "dosresmeta-package", "title": "Multivariate dose-response meta-analysis", "topics": [ "dosresmeta-package" ] }, { "page": "alcohol_crc", "title": "Eight published studies on the relation between alcohol intake and colorectal cancer", "topics": [ "alcohol_crc" ] }, { "page": "alcohol_cvd", "title": "Six published studies on the relation between alcohol intake and cardiovascular disease risk", "topics": [ "alcohol_cvd" ] }, { "page": "alcohol_esoph", "title": "Fourteen case-control studies on the relation between alcohol consumption and esophageal cancer", "topics": [ "alcohol_esoph" ] }, { "page": "alcohol_lc", "title": "Four published studies on the relation between alcohol intake and lung cancer", "topics": [ "alcohol_lc" ] }, { "page": "ari", "title": "Five clinical trials on the relation between aripiprazole and schizophrenia", "topics": [ "ari" ] }, { "page": "blup.dosresmeta", "title": "Best Linear Unbiased Predictions from dosresmeta Models", "topics": [ "blup.dosresmeta" ] }, { "page": "bmi_rc", "title": "Four case-control studies on the relation between Body Mass Index and renal cell cancer", "topics": [ "bmi_rc" ] }, { "page": "cc_ex", "title": "Case-control data on alcohol and breast cancer risk", "topics": [ "cc_ex" ] }, { "page": "ci_ex", "title": "Cumulative incidence data on high-fat dairy food and colorectal cancer risk", "topics": [ "ci_ex" ] }, { "page": "coef.dosresmeta", "title": "Extract Coefficients and (Co)Variance Matrix from dosresmeta Objects", "topics": [ "coef.dosresmeta", "vcov.dosresmeta" ] }, { "page": "coffee_cancer", "title": "Eight prospective studies on the relation between coffee consumption and cancer mortality", "topics": [ "coffee_cancer" ] }, { "page": "coffee_cvd", "title": "Thirteen prospective studies on the relation between coffee consumption and cardiovascular mortality", "topics": [ "coffee_cvd" ] }, { "page": "coffee_mort", "title": "Twenty-one prospective studies on the relation between coffee consumption and all-cause mortality", "topics": [ "coffee_mort" ] }, { "page": "coffee_mort_add", "title": "Additional two prospective studies on the relation between coffee consumption and all-cause mortality", "topics": [ "coffee_mort_add" ] }, { "page": "coffee_stroke", "title": "Eleven prospective studies on the relation between coffee consumption and stroke risk", "topics": [ "coffee_stroke" ] }, { "page": "covar.logrr", "title": "Computes the covariance matrix for a set of log relative risks", "topics": [ "covar.logrr" ] }, { "page": "covar.smd", "title": "Computes mean and standardized mean differences for continuous outcome with corresponding co(variance) matrix", "topics": [ "covar.smd" ] }, { "page": "dosresmeta", "title": "Multivariate Dose-Response Meta-Analysis", "topics": [ "dosresmeta", "dosresmeta.fit" ] }, { "page": "dosresmeta.control", "title": "Ancillary Parameters for Controlling the Fit in dosresmeta Models", "topics": [ "dosresmeta.control" ] }, { "page": "dosresmeta.fixed", "title": "Fixed-Effects Estimator for dosresmeta Models", "topics": [ "dosresmeta.fixed" ] }, { "page": "dosresmeta.ml", "title": "ML and REML Estimators for dosresmeta Models", "topics": [ "dosresmeta.ml", "dosresmeta.reml" ] }, { "page": "dosresmetaObject", "title": "dosresmeta Object", "topics": [ "dosresmetaObject" ] }, { "page": "fish_ra", "title": "Six studies on the relation between fish consumption and rheumatoid arthritis risk", "topics": [ "fish_ra" ] }, { "page": "fpgrid", "title": "Grid with combinations of p for two-order fractional polynomials", "topics": [ "fpgrid" ] }, { "page": "fracpol", "title": "Fractional Polynomials", "topics": [ "fracpol" ] }, { "page": "gof", "title": "Computes statistics to evaluate the goodness-of-fit from dosresmeta Objects", "topics": [ "gof", "print.gof.dosresmeta" ] }, { "page": "grl", "title": "Approximating effective-counts as proposed by Greenland & Longnecker", "topics": [ "grl" ] }, { "page": "hamling", "title": "Approximating effective-counts as proposed by Hamling", "topics": [ "hamling" ] }, { "page": "ir_ex", "title": "Incidence-rate data on fiber intake and coronary heart disease risk", "topics": [ "ir_ex" ] }, { "page": "logLik.dosresmeta", "title": "Extract Log-Likelihood from dosresmeta Objects", "topics": [ "logLik.dosresmeta" ] }, { "page": "milk_mort", "title": "Eleven prospective studies on the relation between milk consumption and all-cause mortality", "topics": [ "milk_mort" ] }, { "page": "milk_ov", "title": "Nine studies on the relation between milk consumption and ovarian cancer", "topics": [ "milk_ov" ] }, { "page": "mlprof.fun", "title": "Likelihood Functions for dosresmeta Models", "topics": [ "iter.igls", "mlprof.fn", "mlprof.fun", "mlprof.gr", "remlprof.fn", "remlprof.gr" ] }, { "page": "oc_breast", "title": "Twenty-two case-control studies on the relation between oral contraceptives use and breast cancer", "topics": [ "oc_breast" ] }, { "page": "predict.dosresmeta", "title": "Predicted Values from dosresmeta Models", "topics": [ "predict.dosresmeta" ] }, { "page": "summary.dosresmeta", "title": "Summarizing dosresmeta Models", "topics": [ "print.dosresmeta", "print.summary.dosresmeta", "summary.dosresmeta" ] }, { "page": "process_bc", "title": "Ten studies on the relation between processed meat and bladder cancer", "topics": [ "process_bc" ] }, { "page": "qtest.dosresmeta", "title": "Cochran Q Test of Heterogeneity for dosresmeta Models", "topics": [ "print.qtest.dosresmeta", "qtest.dosresmeta" ] }, { "page": "red_bc", "title": "Twelve studies on the relation between red meat and bladder cancer", "topics": [ "red_bc" ] }, { "page": "sim_os", "title": "Simulated data for one-stage dose-response meta-analysis", "topics": [ "sim_os" ] }, { "page": "vpc", "title": "Variance Partition Components for dosresmeta Objects", "topics": [ "vpc" ] }, { "page": "waldtest", "title": "Wald Test for Model Coefficients", "topics": [ "print.waldtest", "waldtest" ] } ], "_readme": "https://github.com/alecri/dosresmeta/raw/HEAD/README.md", "_rundeps": [ "mixmeta" ], "_vignettes": [ { "source": "dosresmeta.Rnw", "filename": "dosresmeta.pdf", "title": "dosresmeta", "engine": "knitr::knitr", "headings": [], "created": "2017-09-05 08:53:03", "modified": "2017-09-05 08:53:03", "commits": 1 } ], "_score": 7.057254812602494, "_indexed": true, "_nocasepkg": "dosresmeta", "_universes": [ "alecri" ], "_binaries": [ { "r": "4.7.0", "os": "linux", "version": "2.2.0", "date": "2026-05-15T06:18:12.000Z", "distro": "noble", "commit": "85cfe30a155add28a5a12cba9adf5deb60a457af", "fileid": "5c3b4d1a7d67e70deded07b82660b3b8de13fed23aa0897067285d03766f82c8", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/alecri/actions/runs/25903363092" }, { "r": "4.6.0", "os": "linux", "version": "2.2.0", "date": "2026-05-15T06:17:53.000Z", "distro": "noble", "commit": "85cfe30a155add28a5a12cba9adf5deb60a457af", "fileid": "f1deb273e2f39b2bba07fd64921bd2003a2fa25d26cae4a7eec9488d87c92227", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/alecri/actions/runs/25903363092" }, { "r": "4.5.3", "os": "mac", "version": "2.2.0", "date": "2026-05-15T06:18:20.000Z", "commit": "85cfe30a155add28a5a12cba9adf5deb60a457af", "fileid": "82edcdeda7b54fa2b6e967d24f4233e309fa2e413c0e46c57846716e076b8ee0", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/alecri/actions/runs/25903363092" }, { "r": "4.6.0", "os": "mac", "version": "2.2.0", "date": "2026-05-15T06:17:37.000Z", "commit": "85cfe30a155add28a5a12cba9adf5deb60a457af", "fileid": "4cacc9956a04d23ff378dcb490f680439e89e7b1d2e0d010e64e95403a0345a1", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/alecri/actions/runs/25903363092" }, { "r": "4.7.0", "os": "win", "version": "2.2.0", "date": "2026-05-15T06:16:57.000Z", "commit": "85cfe30a155add28a5a12cba9adf5deb60a457af", "fileid": "b416c2d266299a60cfa2bcb22af3a21928585097da88ca9c4f854aa255ee0163", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/alecri/actions/runs/25903363092" }, { "r": "4.5.3", "os": "win", "version": "2.2.0", "date": "2026-05-15T06:16:48.000Z", "commit": "85cfe30a155add28a5a12cba9adf5deb60a457af", "fileid": "89195615561fbb5ef0002304e7c842e5372257627ec2892a98198484267eebc7", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/alecri/actions/runs/25903363092" }, { "r": "4.6.0", "os": "win", "version": "2.2.0", "date": "2026-05-15T06:16:55.000Z", "commit": "85cfe30a155add28a5a12cba9adf5deb60a457af", "fileid": "bb2d465650180b10c3915df55ae1435c9b6cedec0c41cb2bf424b2df51aa018f", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/alecri/actions/runs/25903363092" }, { "r": "4.6.0", "os": "wasm", "version": "2.2.0", "date": "2026-06-02T20:00:35.000Z", "commit": "85cfe30a155add28a5a12cba9adf5deb60a457af", "fileid": "c92ed50892d5ac66d145e5b581332e6a3196a3ebee94f72d6bc9e003b13eec79", "status": "success", "buildurl": "https://github.com/r-universe/alecri/actions/runs/25903363092" } ] }